The heart’s response to mood changes is significantly influenced by the autonomic nervous system (ANS), which modulates heart rate and rhythm. The hypothalamus, a key structure in the brain, plays a central role in this process. It acts as an important output center for brain regions that regulate mood and serves as a crucial control center for the ANS. The hypothalamus receives and integrates various emotional and psychological inputs and then influences the ANS to adjust cardiac function accordingly. This modulation involves a complex interplay of neurological, hormonal, and psychological factors. Consequently, stress and emotions, processed and mediated by the hypothalamus and other brain regions, can significantly impact heart rate and rhythm
